The solubility of a model basic drug, nortriptyline (Nor), was investigated as a function of pH in phosphate and/or a chloride-containing aqueous suspension using experimental practices recommended in the previously published “white paper” (Avdeef et al., 2016). The pH-Ramp Shake-Flask (pHRSF) method, introduced in our earlier work (Marković et al., 2019), was applied. An improved and more detailed experimental design of the Nor solubility measurement allowed us to exploit the full capacity of the pH-RSF method. Complex equilibria in the aqueous phase (cationic and anionic complex formation between Nor and the phosphate) and solid-phase transformations (Nor free base, 1:1 Nor hydrochloride salt, 1:1 and 1:2 Nor phosphate salts) ...
The solubilities of five sparingly soluble drug-compounds in water were mea-sured at constant temper...
This study was conducted to develop a high throughput screening (HTS) method for the assessment of e...
Additional experimental details; preparation of stock suspensions for low-to-high pH and high-to-low...
The solubility of a model basic drug, nortriptyline (Nor), was investigated as a function of pH in p...
Although solubility-pH data for desipramine hydrochloride (DsHCl) have been reported previously, the...
The purpose of the study was to assess the stoichiometries of phosphate precipitates and determine t...
A novel general approach was described to address many of the challenges of salt solubility determin...
The purpose of the study was to assess the stoichiometries of phosphate precipitates and determine t...
Experimental studies of solubility are important in all phases of drug design and development. Solub...
pH-dependent solubility profile of Desipramine hydrochloride (Ds.HCl) was studied using pH-ramp shak...
The aim of this study was to examine solubility-pH behavior of desipramine structural analogues: im...
This study focuses on the development of mathematical models that explain and predict the combined e...
In this work, the solubilities of lidocaine, thiabendazole, and terfenadine and their salts were mea...
The “anomalous solubility behavior at higher pH values” of several acidic drugs originally studied b...
The solubility of DCPD and TCP in salt solutions of Na2SO4, NaCl, KCl, MgCI2, CaCl2, and a mixture ...
The solubilities of five sparingly soluble drug-compounds in water were mea-sured at constant temper...
This study was conducted to develop a high throughput screening (HTS) method for the assessment of e...
Additional experimental details; preparation of stock suspensions for low-to-high pH and high-to-low...
The solubility of a model basic drug, nortriptyline (Nor), was investigated as a function of pH in p...
Although solubility-pH data for desipramine hydrochloride (DsHCl) have been reported previously, the...
The purpose of the study was to assess the stoichiometries of phosphate precipitates and determine t...
A novel general approach was described to address many of the challenges of salt solubility determin...
The purpose of the study was to assess the stoichiometries of phosphate precipitates and determine t...
Experimental studies of solubility are important in all phases of drug design and development. Solub...
pH-dependent solubility profile of Desipramine hydrochloride (Ds.HCl) was studied using pH-ramp shak...
The aim of this study was to examine solubility-pH behavior of desipramine structural analogues: im...
This study focuses on the development of mathematical models that explain and predict the combined e...
In this work, the solubilities of lidocaine, thiabendazole, and terfenadine and their salts were mea...
The “anomalous solubility behavior at higher pH values” of several acidic drugs originally studied b...
The solubility of DCPD and TCP in salt solutions of Na2SO4, NaCl, KCl, MgCI2, CaCl2, and a mixture ...
The solubilities of five sparingly soluble drug-compounds in water were mea-sured at constant temper...
This study was conducted to develop a high throughput screening (HTS) method for the assessment of e...
Additional experimental details; preparation of stock suspensions for low-to-high pH and high-to-low...